Frequency of Bleeding Disorders in Women Presenting with Menorrhagia in North of Iran

Menorrhagia is a common presentation of bleeding disorders, especially vWD in women. The frequency of these disorders in women with menstruation problems is determined in this study. Total of 273 patients in reproductive age with menorrhagia were investigated for bleeding disorders in two steps. Step one includes CBC, PT, PTT and BT tests which were performed for all patients; patients diagnosed with an abnormality in step one, included in the second step on whom VWF: Ag, RCO, factors level, RIPA and platelet aggregometry and specific assay according to abnormality in first step were performed. Out of 273 patients investigated for bleeding disorders, 70 patients had abnormalities in coagulation tests or platelet counts. Frequencies of bleeding disorders for factor deficiency, platelet disorders and vWD were 8, 7.7 and 5.9%, respectively. Furthermore, 5% patients had abnormal PT, PTT or BT with no definite diagnosis. In this study, the most common bleeding disorder was vWD followed by thrombocytopenia. Although other bleeding disorders are rare, in our study a number of them were found. Based on the findings of present research, it can be recommended that every woman with menorrhagia should be offered the above coagulation tests.